Leyuan Li is currently a postdoctoral fellow at the OISB, University of Ottawa, under the supervision of Professor Daniel Figeys and Professor Alain Stintzi.
Research Interests
Her current research focuses on the development and application of in vitro gut microbiome models and high-throughput metaproteomic processes for Rapidly Assay of Individual’s Microbiome (RapidAIM) against xenobiotics. The gut microbiome plays an important role in the host-drug-microbiome interaction. Individual’s gut microbiome is a crucial factor for drug development, and there is wide variation in drug efficacy and toxicity due to an individual’s microbiome response. Moreover, we do not whether most currently used drugs affect the gut microbiome. The individual microbiome’s response to xenobiotics can be tested through in-vitro culturing approaches. L.Y. Li has been working on the RapidAIM workflow for high-throughput screening of the effects of xenobiotics on the individual microbiome, on the basis of culture medium and experimental workflow optimizations. With metaproteomics as a powerful tool, cloud information of responses in functional pathways corresponding to specific taxa can be revealed. RapidAIM is a promising experimental model system for investigating drug-microbiome interactions using individual microbiomes.